Document Type : Original Article
Authors
1
Christ College (Autonomous), Irinjalakuda, (Affiliated to University of Calicut), Kerala
2
Ramavarmapuram Road Thrissur 09 Kerala, India
3
Department of Gynaecology, JMMC& RI, Thrissur, Kerala, India
4
Jubilee Centre for Medical Research, JMMC&RI, Thrissur, Kerala, India
5
Asst Professor General Internal Medicine georges@sah.on ca Critical Care,Internal Medicine Northern Ontario School Of Medicine
6
Christ College (Autonomous), Irinjalakuda, Kerala
7
Dr Suresh Kumar R. PhD. Scientist B2 Jubilee Centre for Medical Research Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India- 680005
10.22074/ijfs.2024.1974120.1406
Abstract
Background: Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine conditions that significantly impact the life quality of reproductively aged women. In the Indian population, the prevalence varies from 3.7 to 22.5% depending on ethnicity and diagnostic criteria. Chronic inflammation plays a pivotal role in PCOS pathogenesis. The Monocyte Chemoattractant Protein-1 (MCP-1) is an important chemotactic factor for monocytes in an inflammatory response. Genetic variations in MCP-1 may modulate MCP-1 expression. Although the association of the MCP-1 promoter polymorphism (-2518A/G) was extensively studied in different inflammatory conditions, there is only one report in PCOS conditions. Since no study was reported from the Indian population, we aimed to explore the association of the MCP-1 -2518A/G polymorphism (rs1024611) with PCOS.
Materials and Methods: In this case-control study, to analyse the distribution and association of rs1024611 with PCOS, PCR-RFLP analysis was carried out in 202 patients who exhibited PCOS from menarche onwards or with high severity of symptoms and 122 age-matched controls.
Results: In our study, no significance was observed in rs1024611 polymorphism with PCOS patients compared to control samples. In addition to this, we found no significant difference in the genotype and allele frequencies between obese and non-obese PCOS patients.
Conclusion: Our finding suggests that the MCP-1 -2518 A/G polymorphism has not been associated with PCOS predisposition.
Keywords: PCOS, PCR-RFLP, -2518A/G polymorphism
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