Current Issue

Volume 12, Number 4, Jan-Mar 2019 Pages: 273-277

An Overview of The Globozoospermia as A Multigenic Identified Syndrome


Parastoo Modarres, M.S.c, 1, 2, Marziyeh Tavalaee, Ph.D, 1, Kamran Ghaedi, Ph.D, 2, 3, *, Mohammad Hossein Nasr-Esfahani, Ph.D, 1, 3, 4, *,
Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran
Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
Isfahan Fertility and Infertility Center, Isfahan, Iran
*Corresponding Addresses: Department of Cellular Biotechnology Cell Science Research Center Royan Institute for Biotechnology ACECR Isfahan Iran Department of Reproductive Biotechnology Reproductive Biomedicine Research Center Royan Institute for Biotechnology ACECR Isfahan Iran Emails:kamranghaedi@royaninstitute.org,mh.nasr-esfahani@royaninstitute.org

Abstract

Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to failure of in vitro fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI). A variety of processes, organelles and structures are involved in acrosome biogenesis including, trans-golgi network (TGN), acroplaxome and cellular trafficking. This review aims to explain roles of related signals and molecules involved in this process and also describe how their absence in form of mutation, deletion and knockout model may lead to phe- nomenon referred to globozoospermia.