Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR,
Isfahan, Iran
Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran
Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
Isfahan Fertility and Infertility Center, Isfahan, Iran
*Corresponding Addresses:
Department of Cellular Biotechnology
Cell Science
Research Center
Royan Institute for Biotechnology
ACECR
Isfahan
Iran
Department of Reproductive Biotechnology
Reproductive Biomedicine Research Center
Royan Institute for Biotechnology
ACECR
Isfahan
Iran
Emails:kamranghaedi@royaninstitute.org,mh.nasr-esfahani@royaninstitute.org
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ModarresParastoo,
TavalaeeMarziyeh,
GhaediKamran,
Nasr-EsfahaniMohammad Hossein.
An Overview of The Globozoospermia as A Multigenic
Identified Syndrome .
Int J Fertil Steril.
2019;
12(4): 273-277.
Abstract
Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to
failure of in vitro fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI). A variety
of processes, organelles and structures are involved in acrosome biogenesis including, trans-golgi network (TGN),
acroplaxome and cellular trafficking. This review aims to explain roles of related signals and molecules involved in
this process and also describe how their absence in form of mutation, deletion and knockout model may lead to phe-
nomenon referred to globozoospermia.