Past Issue

Volume 12, Number 4, Jan-Mar 2019, Pages: 267-272

Possible Mechanisms for The Effects of Calcium Deficiency on Male Infertility

Asghar Beigi Harchegani, M.Sc, 1, Ali Irandoost, M.Sc, 1, Mahdiyeh Mirnamniha, M.Sc, 2, Hamid Rahmani, M.Sc, 1, Eisa Tahmasbpour, Ph.D, 3, *, Alireza Shahriary, Ph.D, 1, *,
Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
Department of Medical Radiation Engineering, Central Tehran Branch, Islamic Azad, Tehran, Iran
Laboratory of Regenerative Medicine and Biomedical Innovations, Pasteur Institute of Iran, Tehran, Iran
*Corresponding Addresses: P.O.Box: 19945-581 Chemical Injuries Research Center Systems Biology and Poisonings Institute Baqiatallah University of Medical Sciences Tehran Iran P.O.Box: 1316943551 Laboratory of Regenerative Medicine and Biomedical Innovations Pasteur Institute of Iran Tehran Iran,


Calcium (Ca) is a significant element that acts as an intracellular second messenger. It is necessary for many physi- ological processes in spermatozoa including spermatogenesis, sperm motility, capacitation, acrosome reaction and fertilization. Although influences of Ca deficiency on sperm function and male infertility have been widely studied, mechanisms for these abnormalities are not well considered. Poor sperm motility, impairment of chemotaxis, capaci- tation, acrosome reaction and steroidogenesis are the major mechanisms by which Ca deficiency induces male infertil- ity. Therefore, an optimal seminal Ca concentration is required to strengthen sperm function and all steps leading to successful fertilization. Furthermore, identification of these mechanisms provides valuable information regarding the mechanisms of Ca deficiency on male reproductive system and the way for developing a better clinical approach. In this review, we aim to discuss the proposed cellular and molecular mechanisms of Ca deficiency on male reproductive system, sperm function and male fertility. Also we will discuss the valuable information currently available for the roles of Ca in male reproduction.