Current Issue

Volume 12, Number 4, Jan-Mar 2019, Pages: 316-323

Dietary Patterns and The Outcomes of Assisted Reproductive Techniques in Women with Primary Infertility: A Prospective Cohort Study

Maryam Jahangirifar, B.Sc, 1, Mahboubeh Taebi, M.Sc, 2, *, Mohammad Hossein Nasr-Esfahani, Ph.D, 3, *, Gholamreza Askari., Ph.D, 4,
Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Department of Midwifery and Reproductive Health, Woman's Health Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Addresses: P.O.Box: 8174673461 Department of Midwifery and Reproductive Health Woman's Health Research Center Isfahan University of Medical Sciences Isfahan Iran P.O.Box: 815935868 Department of Cellular Biotechnology Cell Science Research Center Royan Institute for Biotechnology ACECR Isfahan Iran,



Infertility is one of the most common challenges that women in reproductive age would encounter today. The maternal nutritional status could be a determinant of oocyte quality and embryonic growth. This study was conducted to assess the relationship between dietary patterns and reproductive outcomes in infertile women.

Materials and Methods

This prospective cohort study was conducted on 140 women with primary infertility who had referred to Isfahan Fertility and Infertility center, Isfahan, Iran. The average number of total oocytes and metaphase II oocytes, the fertilization rate, the ratio of good and bad quality embryo and biochemical and clinical pregnancy were considered as the outcomes of assisted reproductive techniques (ART). A 168-item food frequency questionnaire was used for estimating the dietary intakes during the last year. Factor analysis was used for identifying the dietary patterns and analysis of variance (ANOVA), analysis of covariance (ANCOVA), chi-square, and logistic regression analysis were used for assessing the relation between dietary patterns and ART’s outcomes.


Three major dietary patterns (the healthy, western and unhealthy diet) were identified. Women with high adherence to the “healthy diet” had a higher educational level and were employed. There was a significant increase in the average number of total oocytes (P-trend=0.009) and metaphase II oocytes (P-trend=0.006) in the third tertile of “healthy diet” compared to the first tertile. Also, women with high adherence to the second tertile of “unhealthy” diet compared to the first tertile, had a significantly lower chance of getting pregnant [odds ratio (OR): 0.14, 95% confidence interval (CI): 0.3-0.7].


Nutrition status could affect infertility treatment outcomes. Greater adherence to the healthy diet may enhance oocyte quality and quantity. Unhealthy diet could adversely affect the chance of getting pregnant.