Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran
Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Pediatrics, Behbahan Faculty of Medical Sciences, Behbahan, Iran
School of Nursing and Midwifery, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran
Student Research Committee, School of Nursing, Midwifery, and Paramedicine, Guilan University of Medical Sciences, Rasht, Iran
Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
Dezful University of Medical Sciences, Dezful, Iran
Health Research Center
Tabriz University of Medical Sciences
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Yekta KooshaliMohammad Hossein,
Prevalence of Chlamydia trachomatis in Pregnant Iranian
Women: A Systematic Review and Meta-Analysis .
Int J Fertil Steril.
Several studies have been conducted regarding the prevalence of Chlamydia trachomatis, Mycoplasma hominis, and Ureaplasma urealyticum in pregnant Iranian women. However, it is necessary to combine the previous results to present a general
assessment. We conducted the present study based on systematic review and meta-analysis studies according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We searched the national and international
online databases of MagIran, IranMedex, SID, MedLib, IranDoc, Scopus, PubMed, ISI Web of Knowledge, and Google
Scholar search engine for certain MeSH keywords until June 16, 2017. In addition, heterogeneity, sensitivity analysis, subgroup analysis, and publication bias were performed. The data were analyzed using random-effects model and Comprehensive Meta-Analysis version 2 and P value was considered lower than 0.05. The prevalence of Chlamydia trachomatis in 11
surveyed articles that assessed 2864 pregnant Iranian women was 8.74% [95% confidence interval (CI): 5.40-13.84]. The
prevalence of Chlamydia trachomatis was estimated 5.73% (95% CI: 2.09-14.73) and 13.55% (95% CI: 11.23-16.25) by
enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR), respectively which the difference was
not significant (P=0.082). The lowest and highest prevalence of Chlamydia trachomatis was estimated in Tehran province
[4.96% (95% CI: 2.45-9.810)] and Ardabil province [28.60% (95% CI: 20.61-38.20)], respectively. This difference was
statistically significant (P<0.001). Meta-regression for the prevalence of Chlamydia trachomatis based on year of the studies
was significant with increasing slope (P=0.017). According to the systematic review, the prevalence of Mycoplasma hominis
and Urea plasma urealyticum indicated 2 to 22.8% (from 4 articles) and 9.1 to 19.8% (from 3 articles), respectively. There
was no evidence of publication bias (P value for Begg and Eggers’ tests was 0.161 and 0.173, respectively). The prevalence
of Chlamydia trachomatis is high among pregnant Iranian women. Screening pregnant women as part of preventive measures seem necessary considering the potential for maternal and fetal complications.