Past Issue

Volume 11, Number 4, Jan-Mar 2018, Pages: 309-313

Comparison of In Vitro Fertilization/Intracytoplasmic Sperm Injection Cycle Outcome in Patients with and without Polycystic Ovary Syndrome: A Modified Poisson Regression Model

Amir Almasi-Hashiani, M.Sc, 1, 2, Mohammad Ali Mansournia, M.D., Ph.D, 2, Mahdi Sepidarkish, M.Sc, 1, Samira Vesali, M.Sc, 1, Azadeh Ghaheri, M.Sc, 1, Arezoo Esmailzadeh, M.D, 3, Reza Omani-Samani, M.D., Ph.D, 1, *,
Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Department of Obstetrics and Gynecology, Zahedan University of Medical Sciences, Zahedan, Iran
*Corresponding Address: P.O.Box: 16635-148 Department of Epidemiology and Reproductive Health Reproductive Epidemiology Research Center Royan Institute for Reproductive Biomedicine ACECR Tehran Iran Email:



Polycystic ovary syndrome (PCOS) is a frequent condition in reproductive age women with a prevalence rate of 5-10%. This study intends to determine the relationship between PCOS and the outcome of assisted reproductive treatment (ART) in Tehran, Iran.

Materials and Methods

In this historical cohort study, we included 996 infertile women who referred to Royan Institute (Tehran, Iran) between January 2012 and December 2013. PCOS, as the main variable, and other potential confounder variables were gathered. Modified Poisson Regression was used for data analysis. Stata software, version 13 was used for all statistical analyses.


Unadjusted analysis showed a significantly lower risk for failure in PCOS cases compared to cases without PCOS [risk ratio (RR): 0.79, 95% confidence intervals (CI): 0.66-0.95, P=0.014]. After adjusting for the confounder variables, there was no difference between risk of non-pregnancy in women with and without PCOS (RR: 0.87, 95% CI: 0.72-1.05, P=0.15). Significant predictors of the ART outcome included the treatment protocol type, numbers of embryos transferred (grades A and AB), numbers of injected ampules, and age.


The results obtained from this model showed no difference between patients with and without PCOS ac- cording to the risk for non-pregnancy. Therefore, other factors might affect conception in PCOS patients.