Current Issue

Volume 12, Number 2, Jul-Sep 2018 Pages: 169-172

Effects of Varicocelectomy on Serum Testosterone Levels among Infertile Men with Varicocele


Meysam Jangkhah, M.Sc, 1, 2, *, Faramarz Farrahi, M.D, 2, *, Mohammad Ali Sadighi Gilani, M.D, 2, 3, Seyed Jalil Hosseini, M.D, 2, 4, Farid Dadkhah, M.D, 2, Reza Salmanyazdi, DCLS, 2, Mohammad Chehrazi, Ph.D, 5,
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Department of Urology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Infertility and Reproductive Health Research Center, Shahid Beheshti Medical University, Tehran, Iran
Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproduc- tive Biomedicine, ACECR, Tehran, Iran
*Corresponding Addresses: P.O.Box: 16635-148 Department of Embryology Reproductive Biomedicine Research Center Royan Institute for Reproductive Biomedicine ACECR Tehran Iran Department of Andrology Reproductive Biomedicine Research Center Royan Institute for Reproductive Biomedicine ACECR Tehran Iran Emails:mjangkhah@yahoo.com,farrahief@yahoo.comRoyan Institute

Abstract

Background

The main purpose of this study is to evaluate the effects of varicocelectomy on serum testoster- one levels and semen quality in infertile men who suffer from varicocele.

Materials and Methods

This prospective study enrolled 115 subjects with clinical varicocele grades II and III and 240 fertile men as the control group. Total volume of testosterone serum level (ng/dl) and semen quality were com- pared before and after microscopic varicocelectomy. We normalized testosterone serum levels for age, grade, and testis size basis. SPSS 20 software was used to analyze the data. All results of continuous variables were reported as mean ± SD. Statistical significance was set at a P<0.05.

Results

The mean ages of individuals who participated in the treatment (32.2 ± 5.23) and control (32.8 ± 5.27) groups were similar. There were similar mean values for adjusted testosterone levels between the varicocele (567 ± 222 ng/ml) and control (583 ± 263 ng/ml) groups. In the varicocele group, the adjusted testosterone levels insig- nificantly increased to 594 ± 243 ng/ml. Among semen parameters, only mean sperm concentration significantly increased after varicocelectomy.

Conclusion

Despite increases in sperm concentration, adjusted testosterone levels did not significantly improve after varicocelectomy.