Assessment of DPY19L2 Deletion in Familial and
Non-Familial Individuals with Globozoospermia and
Globozoospermia is a rare syndrome with an incidence of less than 0.1%
among infertile men. Researchers have recently identified a large deletion, about 200 kbp,
encompassing the whole length of
Materials and Methods
In this experimental study, genome samples were collected from 27 men with globozoospermia (cases) and 36 fertile individuals (controls), and genomic analysis was carried out on each sample.
This technique may be considered as a method for family counseling and has the potential to be used as a pre-implantation genetic diagnosis, especially in ethnic community with high rate of consanguineous marriages.