Past Issue

Volume 11, Number 3, Oct-Dec 2017 Pages: 220-225

Tehran Survey of Potential Risk Factors for Multiple Births

Reza Omani Samani, M.D, 1, Amir Almasi-Hashiani, M.Sc, 1, Samira Vesali, M.Sc, 1, Fatemeh Shokri, M.Sc, 1, Rezvaneh Cheraghi, M.Sc, 1, Farahnaz Torkestani, M.D, 2, Mahdi Sepidarkish, M.Sc, 1, *,
Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Department of Obstetrics and Gynecology, Shahed University of Medical Sciences, Tehran, Iran
*Corresponding Address: P.O.Box: 16635-148 Department of Epidemiology and Reproductive Health Reproductive Epidemiology Research Center Royan Institute for Reproductive Biomedicine ACECR Tehran Iran



The multiple pregnancy incidence is increasing worldwide. This increased incidence is concerning to the health care system. This study aims to determine the frequency of multiple pregnancy and identify factors that affect this frequency in Tehran, Iran.

Materials and Methods

This cross-sectional study included 5170 mothers in labor between July 6-21, 2015 from 103 hospitals with Obstetrics and Gynecology Wards. The questionnaire used in this study consisted of five parts: demographic characteristics; information related to pregnancy; information related to the infant; information regarding the multiple pregnancy; and information associated with infertility. We recruited 103 trained midwives to collect data related to the questionnaire from eligible participants through an interview and medical records review. Frequencies and odds ratios (OR) for the association between multiple pregnancy and the selected characteristics (maternal age, economic status, history of multiple pregnancy in first-degree relatives, and reproductive history) were computed by multiple logistic regression. Stata software, version 13 (Stata Corp, College Station, TX, USA) was used for all statistical analyses.


Multiple pregnancy had a prevalence of 1.48% [95% confidence interval (CI): 1.19-1.85]. After controlling for confounding variables, we observed a significant association between frequency of multiple pregnancy and mother’s age (OR=1.04, 95% CI: 1.001-1.09, P=0.044), assisted reproductive technique (ART, OR=6.11, 95% CI: 1.7- 21.97, P=0.006), and history of multiple pregnancy in the mother’s family (OR=5.49, 95% CI: 3.55-9.93, P=0.001).


The frequency of multiple pregnancy approximated results reported in previous studies in Iran. Based on the results, we observed significantly greater frequency of multiple pregnancy in older women, those with a history of ART, and a history of multiple pregnancy in the mother’s family compared to the other variables.