Past Issue

Volume 10, Number 3, Oct-Dec 2016, Pages: 267-269

Male Infertility during Antihypertensive Therapy: Are We Addressing Correctly The Problem?

Antonio Simone Laganà, M.D., 1, *, Salvatore Giovanni Vitale, M.D., 1, Paola Iaconianni, M.D., 2, Simona Gatti, M.D., 2, Francesco Padula, M.D., 3,
Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University of Messina, Messina, Italy
Department of Reproductive Medicine, Altamedica Fetal Maternal Medical Centre, Rome, Italy
Department of Prenatal Diagnosis, Altamedica Fetal Maternal Medical Centre, Rome, Italy
*Corresponding Address: Unit of Gynecology and Obstetrics Department of Human Pathology in Adulthood and Childhood “G. Barresi” University of Messina Via C. Valeria 1 98125 Messina Italy Email:


Male fertility significantly decreased in the last 50 years, as showed in several studies reporting a reduction of sperm counts per ml in the seminal fluid. Several “acute” pharmacological treatments, as antibiotics, could cause subclinical and temporary reduction of male fertility; conversely, long-term medical treatment may severely affect male fertility, although this effect could be considered transient in most of the cases. Thus, nowadays, several long-term pharmacological treatments may represent a clinical challenge. The association between several kind of antihypertensive drugs and reduction of male fertility has been showed in the mouse model, although the modification(s) which may alter this fine-regulated machinery are still far to be elucidated. Furthermore, well-designed observational studies and randomized controlled trials are needed to accurately define this association in human model, meaning a narrative overview synthesizing the findings of literature retrieved from searches of computerized databases. We strongly solicit future human studies (both observational and randomized clinical trials) on large cohorts with adequate statistical power which may clarify this possible association and the effects (reversible or permanent) of each drug. Furthermore, we suggest a close collaboration between general practitioners, cardiologists, and andrologists in order to choose the most appropriate antihypertensive therapy considering also patient’s reproductive desire and possible risk for his fertility.