In today's worlds of advanced technology, obesity phenomenon, more than whatever seen before, is a risk and health- threatening factor. Recent studies show that there is a relation between obesity and infertility in men.
Materials and methods
This paper is written with an overview of related articles published in Sciencedirect, Pubmed,SID and Iranmedex for articles from the inception of each database to March 2015.
The studies showed that obesity with an impaired level of nitric oxide, reduce blood perfusion; with formation of free radicals of oxygen also impaired hormonal axis as a relative hypogonadotropic hypogonadism, and lead to spermatogenesis disorder and infertility. The results of some studies show that obesity in men reduced fertility with decreasing in levels of testosterone, Inhibin B, SHBG, gherlin and increase estrogen and leptin. Related erectile dysfunction and hyperthermia in testis are the most important physical factors in men’s subfertility. Metabolic syndrome in relation to central obesity, with cardiovascular disorder, insulin hypersensitivity and dyslipidemia decreases the chance of male fertility. In vitro studies showed that high-fat diet also increase oxidative stress, and reduces nitric oxide and testosterone level. Some studies also showed a significant positive correlation between BMI and sperm morphology, levels of LH, FSH and leptin.
Obesity as a physical factor related to the life style, can cause reduced fertility in men. Therefore, according to these studies, any intervention to reduce weight, improve endocrine system and basal metabolism, leads to an increase in sperm quality.