P-99: Relationships between Serum Luteinizing Hormone Level, Endometrial Thickness and Body Mass Index in Polycystic Ovary Syndrome Patients with and without Endometrial Hyperplasia.
It is well documented that ulterasonographic endometrial hyperplasia in polycystic ovary syndrome (PCOS) women is strongly related to pathologic endometrial thickness, but there is no consensus on the relation between serum luteinizing hormone (LH) and either of these factors: pathologic endometrial hyperplasia and body mass index (BMI).���
Materials and methods
An observational cross-sectional study was designed. Three hundred fifty infertile PCOS women were involved. An endometrial biopsy was taken by using a pipelle instrument, regardless of menstrual cycle�s day and all samples were reported by the same pathologist. Basal serum LH was compared in two subgroups (hyperplasia and non-hyperplasia). The studied population was divided into three groups according to BMI and basal serum LH and the comparison was made in three groups. Chi-square test, Mann- Whitney U and one way analysis of variance (ANOVA) tests were used to compare variables among groups.
The frequency of endometrial hyperplasia was 2.6%. Endometrial thickness in the patients with endometrial hyperplasia was significantly higher than that of those with a normal endometrium (10.78 � 3.70 vs. 7.90 � 2.86 respectively, P=0.020). Also, there was no relation between endometrial hyperplasia and serum LH (P= 0.600). The ANOVA test showed serum LH levels were not equal among three BMI groups (P=0.007). Post hoc test revealed that the LH level in normal BMI group was higher than other groups significantly (P=0.005 and P=0.004), but there was no statistical difference between overweight and obese groups (P=0.8). We found no relationship between BMI and endometrial thickness in PCOS patients (P=0.6).�ūw��ʓ�b�
Sonographic endometrial stripe thickness is predictive for endometrial hyperplasia in PCOS women. We could not find any relationship between serum LH level and BMI with endometrial thickness in PCOS patients. However, our study confirmed a diverse relationship between serum LH level and BMI in PCOS patients.