Several recent reviews, based mainly on observational studies, have however identified that micronutrient concentrations in the peri-conception period influence female fertility and embryogenesis, and may prevent adverse pregnancy outcomes.The possible effects on subfertility of two micronutrients(Zinc and Selenium), Components of antioxidant enzymes which are commonly included in oral supplements, are discussed here.
Materials and methods
This is review article.
This is review article. Results: Serum Zn concentrations are almost twice as high as follicular concentrations, although the high expression of Zn transport genes in the oocyte suggests active Zn transport during the first stages of pre-implantation development . SimiSimilar to studies on males,studies report conflicting findings as to whether differences exist in serum Zn concentrations between infertile and fertile women . Lower follicular fluid and serum Zn and selenium levels were found in IVF patients than in fertile women , with normalization to those of fertile women following multivitamin supplementation , although the effect on pregnancy rate was not investigated.
Apart from lowering the malformation risk by periconceptional supplementation of folic acid , substitution with different micronutrients, particularly folic acid , vitamin B6,vitamin C, vitamin D, vitamin E, iodine, selenium,iron , and DHA might have a positive impact on infertility treatment .The multivitamin formulation should take the pathophysiology,clinical studies , and upper limits into account.