Is G-CSF has any effects on cancelled ART cycle due to thin endometrium. This study showed the beneficial effects of G-CSF on thin endometrium. In two previous studies, some beneficial effects were reported and in another no effects were seen.
Materials and methods
In a nonrandomized clinical trial, fifteen cases were evaluated from June 2011 till September 2012. All cases had history of cycle cancellation due to thin endometrium which are referred to our center. They had used estradiol, and sildnafil citrate unsuccessfully in their previous cycle. Intrauterine infusion of G-CSF was done on the day of oocyte pick-up or 5 days before embryo transfer in recipient cycles. Primary outcome was endometrial thickness at least till 6.5 mm and secondary outcome as clinical pregnancy rate and then take home baby. All previous cycle was considered as control for each patient, the mean of age ,gravidity, parity, FSH, were 35.13 ± 9.531, 3(20%), 1(6.6%), 32.78 ± 31.10 mIU/ml, respectively. (46.6%) had diminished ovarian reserve according to the FSH levels and averagely they had 1.2 ± 0.532 cycle cancellation due to thin endometrium.
The G-CSF infused at the day of oocyte puncture or 5 days before embryo transfer, the endometrial thickness reached from 3.593 mm ± to 7.120 mm ± 0.84, the difference was 3.53 mm ± 0.88, and clinical pregnancy rate was 20%, one missed abortion, a mother death at 34 weeks, and a preterm labor at 30 weeks due to PROM.
Remarkable results for a small group of patients who had no choice except cycle cancellation or surrogacy , but respond to G-CSF and acceptable outcome.