P-57: Evaluation of Nonyl Phenol Toxic Effect on Sperm Quality of The Reproductive System in Adult Male Mice
Nonyl phenol (NP) is a degradation product of nonylphenol polyethoxylates, which are widely used in the production of industrial and consumer surfactants. NP a Kind of environmental chemical, is thought to imitate endogenous hormones, inhibit the actions of hormones, and induce reproductive abnormalities. In this study, evaluation of Nonyl phenol toxic effects on reproductive system in adult male mouse.
Materials and methods
In this study, 20 adult male mice randomly divided in 2 groups (N=10), control group received only corn oil and Nonyl phenol group received Nonyl phenol (250 mg/kgbw) for 35 days by gavaged. Sperm analysis (motion, count, morphology and viability) was evaluated at the end of the experiments.
The epididymal sperm counts in the groups that received NP showed significant decreases compared to the control group. Also dead and abnormal sperms significantly increased following NP treatment compared with control. The motility of caudal sperm was reduced significantly with NP treatment.
The present results highly support the idea that NP induces testicular toxicity by adverse effects on the sperm parameters in adult male mice.