Unusual effect of celecoxib may be seen in some patients that have used this drug for a long time. Celecoxib is a form of non-steroidal anti-inflammatory drug (NSAID) that directly targets COX-2, an enzyme responsible for inflammation and pain which is the main feature of celecoxib. The goal of this survey is to assess the effect of celecoxib on male-reproductive system's functions.
Materials and methods
The goal of this experimental survey is to determine the effect of celecoxib on rat reproductive system, on spermatogenesis and on the level of blood testosterone hormone. Histological studies and weight measuring of (testis, prostate, seminal vesicle and epidydimis) and the level of blood testestrone are done. Fifty rats with 200-230 g. weight were selected and compared in 5 groups for 15 days as following: Control group (no drug given), sham group (solvent drug: Di- methyl sulfoxide), 3 cases group (orally celecoxib 10, 20 and 40 mg/kg given daily). In the end of 15 days heart blood sampling for measuring serum testosterone level was accomplished and later the reproductive systems were separated and prepared for histological study.
Differences in sertoli cells were seen in the control and the case groups. So that in the case group (40 mg/kg) number of sertoli cells decreased due to decrease testestrone level. This can cause production of abnormal sperms. Significant differences were seen in the mean weight of prostate per body weight in case group (40 mg/kg) in compared to the control group.
Decreased testosterone hormone were seen in mail rat after using high doses of celecoxib .