Venlafaxine is an anti depression medicine, a part of inhibitor group serotonin and norepinephrine . this medicine is well absorbed through digestive tube. The most important purpose of this survey is to conduct research on the effect of Venlafaxine on Oogenesis in female rats.
Materials and methods
The rats with approximate weight of 250 ± 20 were divided into three groups. The rats received dissolved Venlafaxine in physiological serum in the form of gavage with the concentration of 200, 400 and 600 for the period of 21 days. The control group didn’t receive medicine. After the completion of test period, the slices of Ovary were considered after being stained by using H & E method.
Results reveal that the number of primary follicles and Secondary follicles and corpus luteum in the experimental group, which received venlafaxine, show considerable reduction in comparison with those of control group (P<0.001).
The results indicate that Venlafaxine probably reduces the capability of reproduction and has negative impact on Oogenesis in wistar female rats. Some of the ripple effects gradually disappear when the medicine intake discontinued.