Recurrent pregnancy loss (RPL) is usually defined as three or more consecutive pregnancy losses before 20th gestational week. Many etiological factors have been considered as cause of RPL including genetic factors, uterine anatomical defects, endocrine abnormalities, thrombotic and immunologic factors. Nevertheless, the cause of RPL remains unknown in around half of the patients despite extensive workup, and thus termed idiopathic RPL (IRPL). As endometrium is considered as a fertility determining factor, different molecules and cytokines are suggested to be involved in pathogenesis of RPL. In this presentation, some of important molecular aspects of RPL will be discussed.
Materials and methods