Despite the long history associated with varicocele, it remains one of the most controversial issues in the field of Andrology. The main base of this is our current understanding of the pathophysiology of this disease. This has hampered treatment and management of varicocele, especially regarding why, when and to whom varicocelectomy should be applied. The main molecular pathology of varicocele is related to increased reactive oxygen species (ROS). But recent evidence suggests that other molecular mechanisms, like epigenetic modification, heat shock proteins, apoptosis and ubiquitination-proteasome are also affected in individuals with varicocele. Could understanding of these mechanisms help us with treatment of varicocele? These issues will be discussed during this talk.
Materials and methods