Association of Two Polymorphisms in H2B.W Gene with
Azoospermia and Severe Oligozoospermia in
An Iranian Population
During spermatogenesis, the H2B family, member W (
Materials and Methods
This case control study was conducted in Royan institute during
four-year period (2010–2013). Genetic alteration of two SNPs loci, −9C>T and 368A>G, in
The frequency of allele −9T was significantly higher in CMA group than in patients with SCOS (P<0.05). The haplotype TA (corresponding to simultaneous occur- rence of −9T and 368A) compared with haplotype CA (corresponding to simultaneous occurrence of −9C and 368A) in patients suffering from CMA significantly increased, compared with patients had SCOS (P<0.05). However, statistical studies indicated that in general, the distribution frequencies of −9C>T and 368A>G had no significant difference between the infertile groups and control (P=0.859 and P=0.812, respectively).
This investigation showed that SNP −9C>T might be contribute to CMA in azoo- spermic patients and SNP 368A>G had no correlation with male infertility in Iranian population.