Microdose GnRH Agonist Flare-Up versus Ultrashort GnRH Agonist
Combined with Fixed GnRH Antagonist in Poor Responders of
Assisted Reproductive Techniques Cycles
This study compares the microdose flare-up protocol to the ultrashort gonadotropinreleasing hormone (GnRH) agonist flare combined with the fixed multidose GnRH antagonist protocol in poor responders undergoing ovarian stimulation.
Materials and Methods:
In this randomized clinical trial, 120 women who were candidates for
assisted reproductive techniques (ART) and had histories of one or more failed
There were no significant differences between the groups in the number of used gonadotropin ampoules (p=0.591), duration of stimulation (p=0.610), number of retrieved oocytes (p=0.802), fertilization rate (p=0.456), and the number of transferred embryos (p=0.954). The clinical pregnancy rates were statistically similar in group I (10%) compared with group II (13.3%, p=0.389).
According to our results, there is no significant difference between these protocols for improving the ART outcome in poor responders. Additional prospective, randomized studies with more patients is necessary to determine the best protocol (Registration Number: IRCT201105096420N1).